516 - Weight, Constipation and Urinary Tract Infection in Children Aged 3-12 Years in a Multiethnic Community Hospital

Publication Number: 4506.516

Jessica S. Joseph, Flushing Hospital Medical Center, Flushing, NY, United States; Munam Sami, Flushing Hospital Medical Center, Flushing, NY, United States; Dominique L. Popescu, Jamaica Hospital Medical Center, Medord, NY, United States; Lily Q.. Lew, Flushing Hospital Medical Center, Flushing, NY, United States; Joanna Iris A. Depasupil, Flushing Hospital Medical Center, Whitestone, NY, United States

Background: Constipation and urinary tract infection (UTI) are common in children. Excess body weight has been associated with constipation and risk of UTI.

Objective: To explore the relationship between weight, constipation and UTI in children.

Design/Methods: A retrospective chart review of children aged 3-12 years diagnosed with constipation and UTI between Jan 1, 2021 and Dec 31, 2024. Data extracted from EHR included demographics (age, gender ethnicity), weight and urine culture. Weight percentile for age and gender was classified underweight ( < 5%), normal (5-85%), overweight (>85-95%) and obese (>95%). Data were analyzed using R software, p< 0.05 was considered significant.

Results: Of 434 charts identified, about three-quarters (n=323, 74%) were female with a mean age of 7.0 (SD=2.0) years. Hispanic (71%) followed by Asian (16%) ethnicities were the majority. Constipation was diagnosed more often (n=237, 55%) than UTI (n=165, 38%), and least for both (n=32, 7%). Healthy weight was in half (n=219, 50%), obese in a third (n=137, 32%), overweight in less than a fifth (n=63, 15%) and underweight in remainder (n=15, 3%). While a firth logistic regression was significant (𝜒2(9)=21.6, p=0.01), it showed the odds of comorbidity for underweight (OR=2.77, CI= 0.46-12.05, p= 0.24), overweight (OR= 0.82, CI= 0.21-2.49, p= 0.74) and obese patients (OR= 1.25, CI=0.55-2.79, p=0.59) were not significant. Older age (OR=0.79, CI=0.66-0.95, p=0.01) and male gender (OR=0.22, CI=0.02-0.85, p=0.03) were significantly associated with lower odds of UTI. Using multivariable logistic regression, obesity (OR=1.85, CI=1.08-3.18, p=0.03) and older age (OR=1.45, CI=1.28–1.65, p< 0.001) were associated with increased odds of constipation. Males (OR= 6.83, CI=3.33–15.60, p< 0.001) and children identifying as Asian (OR=2.94, CI=1.52-5.89, p=0.002) also had higher constipation risk compared with Hispanic children as reference. Overweight (OR=0.43, CI= 0.20-0.89, p= 0.025) and obese patients (OR=0.56, CI=0.31-0.99, p=0.05) had lower odds of UTI as did older (OR=0.59, CI=0.50-0.68, p< 0.001), male (OR=0.10, CI=0.04-0.21, p< 0.001) and Asian (OR=0.28, CI=0.14-0.56, p< 0.001) patients. Model fit was acceptable for both outcomes (UTI, AIC=396.5; constipation, AIC=439.9).

Conclusion(s): In our small multiethnic sample, higher weight category was significantly associated with constipation and inversely associated with UTI. Older, obese and males identifying as Asian were more likely to have constipation without UTI. Younger and female patients were more likely to have UTI with constipation.